Major Depression or Clinical depression can be cause by several thing. These are the example of what caused major depression
The wrong usage of medicinal item
using alcohol and other medicinal item which not in accordance to the right usage and dose, or even use it only for pleasure may damage the nervous system and causing major depression.
Sadness from Losing a Loved One or Personal Conflict in Relationship
Having a hard condition in relationship and lose someone special through death, separation, or divorce may lead to overwhelming sadness and causing major depression.
Sleeping Problem
Cannot sleep or often we called "insomnia" is a serious problem that may occur depression.
Social Isolation or Feeling of Being Deprived
This may happen in most of people, although there is no one that isolating him/her, sometimes people always feels like the world is isolate him/herself, and this kind of feeling can lead to major depression.
Certain Medical Condition
The people which have medical conditon such as underactive thyroid, cancer, and long term pain will have huge chance to suffer depression.
Physical and Communication Abuse
Hard and painful experience will always haunt the victim and lead to depression.
Major Life Change
Such as moving, graduation, job change, retirement at first will cause stress and if the people cannot adapt well, it'll cause depression.
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